Dr. Rebekah R. Shippy-McConnell, Ph.D
Dr. Shippy-McConnell is a trained natural products synthetic chemist. She brings a background in the design and synthesis of organic compounds as potential pharmacophores and has prepared families using a variety of organic chemical reactions. Her work has allowed her to gained experience working on scaling products from a milligram to kilogram scale for use in animal studies, pharmacokinetic studies and material products.
She has experience using microwave reactors, flow reactors, and autoclaves. Her experience has gained her extensive knowledge using common analytical techniques for structure determine and purity using HPLC, fluorimeters, NMR spectroscopy, Mass Spectrometry, and gas chromatography. With this knowledge, it has allowed her to be prepared for the large variety of custom synthesis requests at Obiter Research, LLC.
Rebekah coordinates the efforts of the Research Chemists on a multitude of Custom and Contract synthesis projects. She also works in harmony with the Process Development and Production Departments to transition benchtop success to a manufacturing reality in a cost effective manner.
Rebekah R. Shippy, Lin Xiaochen, Sherry S. Agabiti, Jin Li, Brendan M. Zangari, Benjamin J. Foust, Micheal M. Poe, Chia-Hung Christine Hsiao, Olga Vinogaedova, David F. Wiemer and Andrew J. Wiemer, Phosphinophosphonates and their tris-pivaloyloxymethyl prodrugs reveal cooperative butyrophilin activation mechanism. J. Med. Chem. 2017, 60(6), 2373-2382.
Andrew J. Wiemer, Rebekah R. Shippy, Ashely M. Kilcollins, Jin Li, Chia-Hung Christine Hsiao, Rocky J. Barney, Maxwell L. Geng and David F. Wiemer, Evaluation of a 7-methoxycoumarin-3- carboxylic acid ester derivative as a fluorescent, cell-cleavable, phosphonate protecting group. ChemBioChem. 2016, 17(1), 52-55.
Chia-Hung Christine Hsiao, Xiaochen Lin, Rocky J. Barney, Rebekah R. Shippy, Jin Li, Olga Vinogradova, David F. Wiemer, and Andrew J. Wiemer, Synthesis and biological evaluation of a phosphonate phosphoantigen prodrug. Phosphorus, Sulfur, Silicon Relat. Elem. 2015, 190(5-6), 751-753.
Chia-Hung Christine Hsiao, Xiaochen Lin, Rocky J. Barney, Rebekah R. Shippy, Jin Li, Olga Vinogradova, David F. Wiemer, and Andrew J. Wiemer, Synthesis of a Phosphoantigen Prodrug that Potently Activates Vγ9Vδ2 T-Lymphocytes. Chem. Biol. 2014, 21(8), 945-954.
Rebekah R. Shippy, Rocky J. Barney, Ashley M. Kilcollins, Jin Li, Chia-Hung C. Hsiao, Andrew J. Wiemer, David F. Wiemer, Synthesis and biological activity of hydroxymethylbutenyl diphosphate mimics for T-cell activation, Boston, MA, National American Chemical Society Meeting, Medical Chemistry Poster Session, August 19, 2015.
Rebekah R. Shippy, Reid Turner, and James Shriver, An Iterative Strategy for the Synthesis of Oligio-Oxofurans Using Furfural Derivatives, Kearney, NE, Midwest Regional American Chemical Society Meeting, Organic Poster Session, October 8-11, 2008.
Rebekah R. Shippy, Reid Turner, and James Shriver, An Iterative Strategy for the Synthesis of Oligio-Oxofurans Using Furfural Derivatives, Des Moines, IA, Iowa Academy of Science, Oral Presentation, April 18, 2009.
Rebekah R. Shippy, David Brown, Jeff Hitchcock, and H. Pete Kleine, The Exploration of Pd (0) Catalyzed Trimethylsilyl Cyanide Conversion of Vinyl Triflate to α,β Unsaturated Nitriles, Saint Louis, MO, Intern Poster Session, August 8, 2009.