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Dr. Pushechnikov has over 15 years of research experience. His achievements in various fields of synthetic organic chemistry are reflected in 36 peer-reviewed publications and patents.

 

Trained as a chemical engineer and earned his PhD in synthetic organic chemistry, he has broad practical experience in managing interdisciplinary chemical contract research and custom synthesis projects.

 

The combination of applied research background and first-hand knowledge of industrial chemical technologies gives Alexei an advantage in finding optimal and cost-effective solutions for developing new chemical processes and products.

 

​PATENTS

Electrochemical Method for the Production of Betulin Aldehyde. Krasutsky, P. A.; Khotkevych, A. B.; Pushechnikov, A.; Rudnitskaya, A. WO/2006/105357 (US2006/011794, pending).

 

Selective Oxidation of Triterpenes Employing TEMPO. Krasutsky, P. A.; Pushechnikov, A.; Sergeeva, T. WO/2006/105354 (US 20090076290, pending).

 

PUBLICATIONS (34)

2013

Dendritic closomers: novel spherical hybrid dendrimers. Pushechnikov, A.; Jalisatgi, S. S.; Hawthorne, M. F. Chem. Commun., 2013, 49, 3579-3581.

 

2012 (3)

Structural Enrichment of HTS Compounds from Available Commercial Libraries. Petrova, T.; Chuprina, A.; Parkesh, R.; Pushechnikov, A. Med. Chem. Commun., 2012, 3, 571-579.

 

Polyhedral borane derivatives: Unique and versatile structural motifs. Hawthorne, M. F.; Pushechnikov, A. Pure Appl. Chem. 2012, 84, 2279-2288.

 

Probing Over 1 Million Small Molecule-RNA Motif Interactions Simultaneously Via Two-Dimensional Combinatorial Screening. Velagapudi, S. P.; Pushechnikov, A.; Labuda, L. P.; French, J. M.; Disney, M. D. ACS Chem. Biol. 2012, 7, 1902-1909.

 

2010 – 2007 (10)

A Chemoenzymatic Route to Diversify Aminolgycosides Enables A Microarray-Based Method to Probe Acetyltransferase Activity. Tsitovich, P. B.; Pushechnikov, A.; French, J. M.; Disney, M. D. ChemBioChem 2010, 11, 1656-1660.

 

Approach to the Library of Fused Pyridine-4-carboxylic Acids by Combes-Type Reaction of Acyl Pyruvates and Electron-Rich Amino Heterocycles. Volochnyuk, D. M.; Ryabukhin, S. V.; Plaskon, A. S.; Dmytriv, Y. V.; Grygorenko, O. O.; Mykhailiuk, P. K.; Krotko, D. G.; Pushechnikov, A.; Tolmachev, A. A. J. Comb. Chem. 2010, 12, 510-517.

 

The Role of Flexibility in the Rational Design of Modularly Assembled Ligands Targeting the RNAs that Cause the Myotonic Dystrophies. Disney, M. D.; Lee, M. M.; Pushechnikov, A.; Childs-Disney J. L. ChemBioChem 2010, 11, 375-382.

 

Controlling the Specificity of Modularly Assembled Small Molecules for RNA via Ligand Module Spacing: Targeting the RNAs That Cause Myotonic Muscular Dystrophy. Lee, M. M.; Childs-Disney, J. L.; Pushechnikov, A.; Sobczak, K.; French, J. M.; Thornton, C. A.; Disney, M. D. J. Am. Chem. Soc. 2009, 131, 17464-17472.

 

Rational Design of Ligands Targeting Triplet Repeating Transcripts That Cause RNA Dominant Disease: Application to Myotonic Muscular Dystrophy Type 1 and Spinocerebellar Ataxia Type 3. Pushechnikov, A.; Lee, M.; Childs-Disney, J. L.; Sobczak, K.; French, J. M.; Thornton, C. A.; Disney, M. D. J. Am. Chem. Soc. 2009, 131, 9767-9779.

 

Rational and Modular Design of Potent Ligands Targeting the RNA that Causes Myotonic Dystrophy 2. Lee, M.; Pushechnikov, A.; Disney, M. D. ACS Chem. Biol. 2009, 4, 345-355.

 

Small Molecule Microarrays of RNA-Focused Peptoids Help Identify Inhibitors of a Pathogenic Group I Intron. Labuda, L. P.; Pushechnikov, A.; Disney, M. D. ACS Chem. Biol. 2009, 4, 299-307.

 

Studying Aminoglycoside Modification by the Acetyltransferase Class of Resistance-Causing Enzymes via Microarray. Barrett, O. J.; Pushechnikov, A.; Wu, M.; Disney, M. D. Carbohydr. Res. 2008, 343, 2924-2931.

 

Two-Dimensional Combinatorial Screening Identifies Specific Aminoglycoside-RNA Internal Loop Partners. Disney, M. D.; Labuda, L. P.; Paul, D. J.; Poplawski, S. G.; Pushechnikov, A.; Tran, T.; Velagapudi, S. P.; Wu, M.; Childs-Disney, J. L. J. Am. Chem. Soc. 2008, 130, 11185-11194.

 

A Small Molecule Microarray Platform to Select RNA Internal Loop-Ligand Interactions. Childs-Disney, J. L.; Wu, M.; Pushechnikov, A.; Aminova, O.; Disney, M. D. ACS Chem. Biol. 2007, 2, 745-754.

 

2006 – 2004 (2)

The Stereochemistry of Allenic Enol Tautomerism; Independent Generation and Reactivity. Zimmerman, H. E.; Pushechnikov, A. Eur. J. Org. Chem. 2006, 3491-3497.

The Synthesis of a Highly Reactive Heterocylic Reactant and its Unusual Photochemistry; Mechanistic and Exploratory Photochemistry. Zimmerman, H. E.; Pushechnikov, A. Org. Lett. 2004, 6, 3779-3780.

 

2005 – 1997 (18)

Phosphorylation of Arylureas and Arylcarbamates: A New Prospect. Volochnyuk, D. M.; Pushechnikov, A.; Krotko, D. G.; Pinchuk, A. M.; Tolmachev, A. A. Synthesis 2005, 3124-3134.

 

Electron-Rich Aminoheterocycles for Regiospecific Synthesis of CF3-containing Fused Pyridines. Volochnyuk, D. M.; Pushechnikov, A.; Krotko, D. G.; Sibgatulin, D. A.; Kovalyova, S. A.; Tolmachev, A. A. Synthesis 2003, 1531-1540.

 

One-pot synthesis of (5-aminopyrazol-4-yl)-phosphonic acid derivatives from 1-aryl-5-arylcarboxamidopyrazoles through pyrazolo[4,3-c][1,5,2]-oxazaphosphinines. Volochnyuk, D. M.; Pushechnikov, A.; Krotko, D. G.; Koydan, G. N.; Marchenko, A. P.; Chernega, A. N.; Pinchuk, A. M.; Tolmachev, A. A. Synthesis 2003, 906-914.

 

Phosphorylation of electron-rich aromatic and heteroaromatic carboxylic acid derivatives. Chekotylo, A. A.; Pushechnikov, A.; Yurchenko, A. A.; Tolmachev, A. A.; Pinchuk, A. M. Phosphorus, Sulfur, Silicon 2002, 177, 2185.

 

Interaction of izatins with some five-membered aminoheterocycles. Pushechnikov, A.; Volochnyuk, D. M.; Tolmachev, A. A. Synlett 2002, 7, 1140-1142.   

C-phosphorylation of azoles in synthesis of novel fused phosphorus-containing heterocycles. Pinchuk, A. M.; Ivanov, V. V.; Zarudnizkii, E. V.; Pushechnikov, A.; Tolmachev, A. A. Phosphorus, Sulfur, Silicon 2002, 177, 1767-1769.

 

Reactions of 1-substituted benzo[4,5]imidazo[1,2-a]pyridines. Volovenko, Yu. M.; Ivanov, V. V.; Pushechnikov, A.  Chemistry of Heterocyclic Compounds 2002, 38, 213-218.

 

Novel benzodiazaphosphinines with an endocyclic P-C bond. Pushechnikov, A.; Krotko, D. G.; Volochnyuk, D. M.; Tolmachev, A. A. Chemistry of Heterocyclic Compounds 2001, 37, 659-661.

 

An amidine moiety as an N-nucleophilic exo group for constructing condensed phosphorus-containing heterocyclic systems. Pushechnikov, A.; Volochnyuk, D. M.; Krotko, D. G.; Tyltin, A. K.; Tolmachev, A. A.  Chemistry of Heterocyclic Compounds 2001, 37, 656-658.

 

C-Phosphorylated azoles. Pinchuk, A. M.; Yurchenko, A. A.; Oshovsky, G. V.; Zarudnitskii, E. V.; Pushechnikov, A.; Tolmachev, A. A. Polish Journal of Chemistry 2001, 75, 1137-1146.

 

Novel heterocyclic system - 2,4,1-benzoxazaphosphinine: convenient substrate for synthesis of derivatives of 2,4-diaminophenylphosphonic acid. Pushechnikov, A.; Krotko, D. G.; Volochnyuk, D. M.; Tolmachev, A. A. Synlett 2001, 6, 860-862.

 

Dipyrrolophosphinanes. Ivonin, S. P.; Pushechnikov, A.; Tolmachev, A. A. Heteroatom Chemistry 2000, 11, 107-114.

 

Reactions of 1-aryl-2,5-dimethylpyrroles with ketones. Pushechnikov, A.; Ivonin, S. P.; Chaikovskaya, A. A.; Kudrya, T. N.; Pirozhenko, V. V.; Tolmachev, A. A. Chemistry of Heterocyclic Compounds 1999, 35, 1313-1318.   

 

3,5-Bisphosphorylated 4-aryl-1,2,4-triazoles. Tolmachev, A. A.; Zarudnitskii, E. V.; Dovgopoly, S. I.; Pushechnikov, A.; Yurchenko, A. A.; Pinchuk, A. M. Chemistry of Heterocyclic Compounds 1999, 35, 1249-1250.  

 

C-Phosphorylation of electron-rich heterocycles with trivalent phosphorus halides. Tolmachew, A. A.; Chaikovskaya, A. A.; Kopteva, S. D.; Pushechnikov, A.; Ivonin, S. P. Phosphorus, Sulfur, Silicon 1999, 147, 1311-1312.

 

Synthesis and characterization of 4,5-dihydro-1H-pyrazolo[3,4b][1,4] azaphosphinines. Tolmachev, A. A.; Dovgopoly, S. I.; Kostyuk, A. N.; Kozlov, E. S.; Pushechnikov, A.; Holzer, W. Heteroatom Chemistry 1999, 10, 391-398.

 

Diheteroannelated azaphosphepines. Tolmachev, A. A.; Pushechnikov, A.; Krotko, D. G.; Ivonin, S. P.; Kostyuk, A. N. Chemistry of Heterocyclic Compounds 1998, 34, 1098-1099.

 

Phosphorus-containing heterocyclic compounds derived from N-vinylpyrroles. Tolmachev, A. A.; Dovgopoly, S. I.; Kostyuk, A. N.; Kozlov, E. S.; Pushechnikov, A.; Trofimov, B. A.; Mikhaleva, A. I. Heteroatom Chemistry 1997, 8, 495-499.

 

Alexei Pushechnikov, Ph.D.

Chemistry Manager